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邮箱：daihp@yingbio.com 、 huizhang1228@foxmail.comKinases & Phosphatases qBiomarker Copy Number PCR Arrays
激酶和磷酸酶qBiomarker拷贝数PCR芯片 | Product | Species | Technology | Cat. No. |
| Kinases & Phosphatases qBiomarker Copy Number PCR Arrays | Human | Copy Number | VAHS-0001Z |
The Human Kinases & Phosphatases qBiomarker Copy Number PCR Array profiles the copy number of 23 genes encoding kinases or phosphatases reported to undergo frequent genomic alterations. DNA copy number changes in kinases and phosphatases occur frequently in cancer. The genes on the array encode both key kinases and phosphatases that regulate processes such as the cell cycle, insulin and other hormone receptor signaling, PI-3-K signaling, apoptosis, cell migration, and motility. Genes were chosen from the most frequently amplified or deleted kinase and phosphatase genes based on the primary literature and public databases. This array may serve as a useful tool to help classify samples by genotype and help verify phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available
激酶和磷酸酶qBiomarker拷贝数PCR芯片用于研究发生频繁突变的编码激酶和磷酸酶的23个基因的拷贝数。在癌症中经常出现激酶和磷酸酶DNA拷贝数突变。该芯片上的基因编码关键激酶和磷酸酶,这些酶调节细胞周期,胰岛素和其他激素受体信号,PI-3-K信号,细胞凋亡,细胞迁移和能动性等过程。这个芯片基于重要文献和公共数据库，选择最频繁扩增或缺失的激酶和磷酸酶基因。这个芯片可作为一个有帮助分类样本的基因型和验证表型生物标记的有效工具。这个芯片可以使每个基因在每个样本中有四个重复，同时包含一个稳定的多拷贝参考实验，通过适当的DNA插入标准化精确检测拷贝数。简单的产品模式和操作程序让任何一个具备实时定量PCR仪的实验室都可进行常规可靠的拷贝数检测。
qBiomarker拷贝数PCR芯片用于分子生物学应用。本产品不用于疾病的诊断、预防和治疗。
提供96孔板，384 -(4×96)板，和100 孔。
AKT / PI-3-Kinase Signaling: AKT1, AKT2, AKT3, PIK3CA.
Cyclin-Dependent Kinase: CDK4.
Cytoskeleton: AURKA, PTK2, STK11.
MAP Kinase Signaling: MAP2K4.
Metabolism: FHIT, PDK1.
Receptor Tyrosine Kinases & Signaling: ALK, EGFR, ERBB2, FGFR2, IGF1R, MET, PDGFRA, SIK2.
Ribosomal Protein Kinase: RPS6KB1.
Phosphatases: FHIT, PPAPDC1B, PTEN, PTPRD.
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